منابع مشابه
Spindle microtubules in flux.
Accurate and timely chromosome segregation is a task performed within meiotic and mitotic cells by a specialized force-generating structure--the spindle. This micromachine is constructed from numerous proteins, most notably the filamentous microtubules that form a structural framework for the spindle and also transmit forces through it. Poleward flux is an evolutionarily conserved mechanism use...
متن کاملMicrotubules park parallel in the half-spindle
y the late 1970s, it was still unclear how microtubules (MTs) operated in the mitotic spindle. Several pieces of the microtubule puzzle had been worked out: micro-tubules slid past each other to give cilia their movement (Satir, 1968); dynein cross-bridges linked MTs together (Gibbons, 1966); and MT polymers had polarity. That polarity was reflected by both the orientation of asymmetric subunit...
متن کاملOrganization of spindle microtubules in Ochromonas danica
The entire framework of microtubules (MTs) in the mitotic apparatus of Ochromonas danica is reconstructed (except at the spindle poles) from transverse serial sections. Eleven spindles were sectioned and used for numerical data, but only four were reconstructed: a metaphase, an early anaphase, a late anaphase, and telophase. Four major classes of MTs are observed: (a) free MTs (MTs not attached...
متن کاملPolarity of spindle microtubules in Haemanthus endosperm
Structural polarities of mitotic spindle microtubules in the plant Haemanthus katherinae have been studied by lysing endosperm cells in solutions of neurotubulin under conditions that will decorate cellular microtubules with curved sheets of tubulin protofilaments. Microtubule polarity was observed at several positions in each cell by cutting serial thin sections perpendicular to the spindle ax...
متن کاملInterpolar spindle microtubules in PTK cells
Spindle microtubules (MTs) in PtK1 cells, fixed at stages from metaphase to telophase, have been reconstructed using serial sections, electron microscopy, and computer image processing. We have studied the class of MTs that form an interdigitating system connecting the two spindle poles (interpolar MTs or ipMTs) and their relationship to the spindle MTs that attach to kinetochores (kMTs). Viewe...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2005
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.02284